As the creator of HarvestRL (which I'm still working on to some extent) I thought I'd offer some suggestions. Note that I have not tried your game yet, so these comments might already be resolved.
Although Krice could be trolling with his comment, potential boringness is actually something to take seriously. For example, in Harvest Moon/Rune Factory you use a tool by pressing a button and the direction in which you face. So, your character is facing left, he's holding a hoe, and you press a button to till that tile to the left. Then you do this X many times and you're done that task. I attempted to automate this; in HarvestRL, you equip a hoe and then walk onto a tile to till; if you can till it, your character automatically does so. Likewise with watering and harvesting plants. The effect of this is that the task of watering/planting feels much different than in the original game, most obviously because it is faster. I'm attempting some other improvements on making the farming aspect "faster" in terms of button presses and such.
Part of my concern is: if I remove those actions then what is left of the game? Did players enjoy the grindy feeling of repeatedly pressing buttons to water/plant? Or was there something more they enjoyed? While it is definitely possible to just take Harvest Moon and add procedural generation to the landscape / dungeons, you may want to consider how the farming itself is done.
Oddly enough, many of the arguments surrounding the grind of Angband and such games are completely applicable to the non-combat aspects of Harvest Moon. Is it fun to "improve" relationships with townsfolk / potential spouses by repeatedly "talking" to them every in-game day? Could something else be done to make that more fun, or is Harvest Moon enjoyable specifically because of that grind?
There's another game (whose name I forget) that is a farming simulator / tower defense (not Plants vs. Zombies). You farm so as to gather food / materials that are used to strengthen the town and improve the defenses of your farm, and then fight off zombies during particular times. This is not Harvest Moon, but it is something that tried to add on to the farming aspect to make it more interesting / enjoyable. I'm not suggesting you use that idea, but that you consider the "why" behind the farming, even down to every button press that needs to be made. As much as I love Harvest Moon, I quickly tire of the grind; I suspect other people feel the same way. HarvestRL I wanted to enjoy without the grind and I'm still figuring out how best to do that.