I think the system I will be using is a mixture of George and Z's systems. You have 4 stats: Damage (Dmg), Weapon Class (WC), Armor Class (AC), and Negation Rate (NR).
Whether you hit or not is based on WC and AC. If WC - AC ≤ 0, it's a miss. If WC - AC > 0, then you hit with a percentage chance equal to: 14(WC - AC). For example, if a creature's WC is 5 and your AC is 6, it will miss, but if a creature's WC is 4 and your AC is 0, it will have a 56% chance to hit you.
How much you hit is based on Dmg and NR: Dmg - (Dmg * NR). NR is a percent, i.e. if Dmg is 16 and your NR is 10%, then the creature will hit you for 14 damage (Dmg * NR is rounded up)
You can also implement Dmg and NR types, such as Acid, Fire, Ice, etc.